Novel Syntheses of Chiral β- and γ-Amino Acid Derivatives Utilizing N-Protected (Aminoacyl)benzotriazoles from Aspartic and Glutamic Acids

Friedel−Crafts reactions of N-protected (α-aminoacyl)benzotriazoles with hetero- and benzenoid- aromatics give α-amino ketones that can be reduced by either triethyl silane or sodium borohydride to form the corresponding β- and γ-amino acid derivatives. The preservation of chirality throughout this process is confirmed by chiral HPLC results.