Effects of different interventions on virus detoxification in patients with hand, foot and mouth disease caused by other enterovirus infection

Objective To understand the pharyngeal and intestinal detoxification time of hand, foot and mouth disease caused by non-enterovirus 71 and non-coxsackievirus A16 enteroviruses (other EV), and the effect of recombinant human interferon α2b spray on its detoxification time. Methods The data of 159 children with hand, foot and mouth disease caused by other EV infection who were admitted in Hangzhou Children’s Hospital from December 2016 to December 2017 were selected. The stools and pharynx were collected within 2 days after admission, and tested for virus by real-time PCR. The pharyngeal and intestinal detoxification situation of 87 patients with complete diagnosis were followed up. The experimental group was treated with recombinant human interferon α2b spray(52 cases), and the control group was treated with Kaihoujian spray(35 cases). The cumulative conversion rate of two groups were observed. Results The fecal virus nucleic acid in 159 patients were all positive at the first week of treatment, and negative cases occurred at the second week. By the sixth week, all the fecal virus nucleic acid were negative. The cumulative negative rate of pharyngeal detoxification for hand, foot and mouth disease caused by other EV was 54.0%, which was higher than that of the control group(40.0%), but the difference was not statistically significant (χ2=1.382, P>0.05). There was no significant difference in the cumulative negative rate of enterovirus between the two groups (χ2=0.131, P>0.05). Conclusions Enterovirus turns negative in hand, foot and mouth disease children caused by other EV infections in the second week. Recombinant human interferon α2b spray treatment slightly improved the pharyngeal detoxification rate. Key words: Hand, foot and mouth disease; Enteroviruses; IFNα2b; Detoxification time