Synthesis and evaluation of a well-defined HPMA copolymer-dexamethasone conjugate for effective treatment of rheumatoid arthritis.

Xin Ming Liu,Ling Dong Quan,Jun Tian,Yazen Alnouti,Kai Fu,Geoffrey M. Thiele,Dong Wang

Synthesis and evaluation of a well-defined HPMA copolymer-dexamethasone conjugate for effective treatment of rheumatoid arthritis.

2008

Xin Ming Liu
Ling Dong Quan
Jun Tian
Yazen Alnouti
Kai Fu
Geoffrey M. Thiele
Dong Wang

Purpose To develop a pH-sensitive dexamethasone (Dex)-containing N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer conjugate with well-defined structure for the improved treatment of rheumatoid arthritis (RA).

Keywords:

Corticosteroid
Methacrylamide
Conjugate
Rheumatoid arthritis
Copolymer
Dexamethasone
Immunology
Indexation
Biochemistry
Chemistry
Drug delivery
Pharmacology
effective treatment

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