MP16-12 THE PRIMARY IRON UPTAKE RECEPTOR, TRANSFERRIN RECEPTOR 1, MEDIATES HIF-2α OVEREXPRESSION AND PROLIFERATION IN CLEAR CELL RENAL CELL CARCINOMA CELLS

Thomas Siff,Christopher Greene,Nikita Sharma,Peter N. Fiorica,Arun Menon,Gary D. Smith,Kenneth W. Gross,Eric Kauffman

MP16-12 THE PRIMARY IRON UPTAKE RECEPTOR, TRANSFERRIN RECEPTOR 1, MEDIATES HIF-2α OVEREXPRESSION AND PROLIFERATION IN CLEAR CELL RENAL CELL CARCINOMA CELLS

2019

Thomas Siff
Christopher Greene
Nikita Sharma
Peter N. Fiorica
Arun Menon
Gary D. Smith
Kenneth W. Gross
Eric Kauffman

INTRODUCTION AND OBJECTIVES:The main dysregulated pathway of clear cell renal cell carcinoma (ccRCC), the von Hippel Lindau (VHL)/hypoxia inducible factor-α (HIF-α) axis, is a key regulator and reg...

Keywords:

Pathology
Transferrin receptor
Cancer research
Receptor
Medicine
Clear cell renal cell carcinoma
von hippel lindau
Hypoxia-inducible factors
Regulator
iron uptake

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