ESTIMATION OF GLYCATED ALBUMIN LEVELS IN VARIOUS THYROID DISORDERS

Background: Glycation is the linking of sugar molecule to various compounds such as glucose, lipid or protein. As albumin is one of major protein in our circulation, to which sugar has bonded to form Glycated albumin. Albumin is present not only in blood but also in major organs and body fluids and it serves to maintain cell shape and distribution of hormones. Objective: The present study was designed to compare the levels of GA in Various thyroid disorders group with Normal healthy control group. Materials and Methods:The present cross sectional study includes 200 cases, (n=50 in each group) newly diagnosed hyperthyroidism, hypothyroidism, subclinical hypothyroidism and normal controls between 30-55 years of both genders.serum samples obtained for the estimation of T3,T4,TSH and glycated albumin. Statistical analysis done by using SPSS, version16.0. One-way ANOVA was performed. All P-values which were ≤0.05 were considered as stastically significant. Results: Glycated albumin values were found to be significantly correlated among the different groups (p=0.001). GA levels significantly increased in hypothyroidism, subclinical hypothyroidism and lowered in hyperthyroidism group compared to normal group. Significant correlation was found between T3, T4, TSH and GA levels. Conclusion: The present study showed increased levels of GA among experimental groups when compared with the normal control group. Hence It was concluded that estimation of serum GA will be useful as a noval parameterin thyroid disease cases.