Raf kinase inhibition of using heterocyclic substituted ureas.

A method for treating growth of cancer cells mediated by raf kinase comprising administering a compound of formula I ** ** formula wherein B is an aryl or substituted or unsubstituted heteroaryl, tricyclic up having up 30 carbon atoms with at least one aromatic structure of 5 or 6 members containing 0-4 members of the group consisting of nitrogen, oxygen and sulfur, wherein if B is a substituted group is substituted conunoo more substituents independently selected from the group consisting of halogen, up to per-halosubstitution, and Xn, wherein n is 0-3 and each X is independently selected from the group consisting of -CN, -CO2R5, -C (O) NR5 R5 ', -C (O ) R5, -NO2, -OR5, -SR5, -NR 5 R 5 ', -NR 5 C (O) OR5', -NR 5 C (O) R5 ', C1-C10 alkyl, C2-C10, C1 C10, C3-C10, C6-C14 aryl, alkaryl-C24 C7, C3-C13 heteroaryl, C4 alk-heteroaryl-C23, C1-C10 substituted alkyl, C2-C10 substituted, C1-C10 alkyl, substituted C3-C10 cycloalkyl, C4 alk-heteroaryl-C23 substituted and -Y-Ar; in wherein if X is a substituted group, it is substituted by one or more substituents independently selected from the group consisting of -CN, -CO2R5, -C (O) R5, -C (O) NR5 R5 ', -OR5, -SR 5, -NR 5 R 5 ', -NO 2, -NR 5 C (O) R 5', -NR 5 C (O) OR5 'and halogen up to per-halosubstitution; in which formulas R5 and R5 'are independently selected from H, C1-C10 alkyl, C2-C10 alkenyl, C3-C10 aryl, C6-C14 heteroaryl C3-C13 alkaryl, C7-C24, alk-heteroaryl C4-C23 , C1-C10 alkyl up to per-halosubstituted C2-C10 alkenyl, up to per-halosubstituted C3-C10 cycloalkyl, up to per-halosubstituted C6-C14 aryl up to per-halosubstituted heteroaryl C3-C13 up to per-halosubstituted, in which formulas Y is -O-, -S-, -N (R5) -, - (CH2) -m, -C (O) -, -CH (OH) -, - (CH2) mO-, -NR 5 C (O) NR5 NR5 '-, -NR 5 C (O) -, -C (O) NR5 -, - (CH2) ms-, - (CH2) mN (R5) -, -O (CH2) m-, -CHX to , -CX a2-, -S- (CH2) m- and -N (R5) (CH2) m-, m = 1-3, and X a is halogen; and Ar is an aromatic 5-10 membered structure containing 0-4 members of the group consisting of nitrogen, oxygen and sulfur which is unsubstituted or substituted by halogen up to per-halosubstitution and optionally substituted by Zn1, wherein n1 is 0 to 3 and each Z is independently selected from the group consisting of -CN, = O, -CO2R5, -C (O) NR5 R5 ', -C (O) NR 5, -NO 2, -OR 5, -SR 5, -NR 5 R 5' ' , -NR 5 C (O) OR5 ', -C (O) R 5, -NR 5 C (O) R5', -SO2R5, SO2NR5 R5 ', C1-C10, C1-C10 alkoxyl, C3-C10 , C6-C14 aryl, C3-C13 heteroaryl, C7-C24 alkaryl, C4 alk-heteroaryl-C23, C1-C10 substituted alkyl, C3-C10 substituted alkaryl and substituted C7-C24 alk-heteroaryl substituted C4-C23; in which formulas, if Z is a substituted group is substituted with one or more substituents independently selected from the group consisting of -CN, -CO2R5, -C (O) NR5 R5 ', = O, -OR 5, -SR 5, -NO 2, -NR 5 R 5 ', -NR 5 C (O) R 5', -NR 5 C (O) OR5 ', C1-C10 alkyl, C1-C10, C3-C10 cycloalkyl, C3-C13 heteroaryl, aryl C6-C14, alk-heteroaryl C4-C24 alkaryl C7-C24, and A is a heteroaryl moiety selected from the group consisting ** formula ** in which formulas R1 is selected from the group consisting of halogen, C3-C10 cycloalkyl, C3-C10, C1-C13 heteroaryl, C6-14 aryl, C7-24 alkaryl, C1-C10 alkyl up to per-halosubstituted C3-C10 cycloalkyl, up to per-halosubstituted C1-C13 heteroaryl, up to per-halosubstituted C6-14 aryl up to per-halosubstituted C7-24 alkaryl up to per-halosubstituted; R2 is selected from the group consisting of H, -C (O) R4, -CO2R4, -C (O) NR3 R3 ', C1-C10 alkyl, C3-C10, C24-alkaryl C7, C4 alk-heteroaryl-C23 , C1-C10 alkyl, C3-C10 substituted alkaryl C7-C24 substituted and alk-heteroaryl C4-C23 substituted, in the case where R2 is a substituted group is substituted conuno or more substituents independently selected from the group consisting of -CN, -CO2R4, -C (O) -NR3 R3 ', -NO2, -OR4, -SR4, and halogen up to per-halosubstitution, wherein R3 and R3' are independently from the group consisting of H, -OR4 , -SR4, -NR4 R4 ', -C (O) R4, -CO2R4, -C (O) NR4 R4', C1-C10 alkyl, C3-C10 cycloalkyl, C6-C14 aryl, C3-C13 heteroaryl, alkaryl C7-C24 alk-heteroaryl C4-C23, C1-C10 alkyl up to per-halosubstituted C3-C10 up to per-halosubstituted aryl C6-C14 up to per-halosubstituted heteroaryl C3-C13 up to per-halosubstituted; and in which formulas R4 and R4 'are independently from the group consisting of H, C1-C10 alkyl, C3-C10 cycloalkyl, C6-C14 aryl, heteroaryl C3-C13, alkaryl C7-C24 alk-heteroaryl C4-C23, C1-C10 alkyl up to per-halosubstituted C3-C10 cycloalkyl, up to per-halosubstituted C6-C14 aryl up to per-halosubstituted heteroaryl C3-C13 up to per-halosubstituted R a is C1-C10 alkyl, C3-C10, alkyl C1-C10 up to per-halosubstituted C3-C10 cycloalkyl, up to per-halosubstituted; and R b is hydrogen or halogen, Rc is hydrogen, C1-C10 alkyl, C1-C10 alkyl up to per-halosubstituted or combines with R1 and the carbon atoms to which are attached R1 and R c to form a ring cycloalkyl, aryl or hetarilode5 or 6 membered with 0-2 members selected from O, N and S; with the proviso that, in the case where A is ** ** B is formula ** ** formula in which formula n = 2-4, or ** ** formula.