Wonton-like Nanoparticles with Dual Enzyme-mimetic Function for the Multiple-imaging-guided Cancer Combined Therapy

Abstract The significant role of some natural enzymes in tumor therapy is recently widely explored due to their catalyzing specific endogenous substrates in tumor part. However, the catalytic activity of these natural enzymes differs in various and complex tumor microenvironment, which eventually is difficult to be guaranteed. To address this issue, a new wonton-like Bi@PVP@AuPt nanoparticle with both glucose oxidase- and peroxidase-like enzyme function were designed to replace natural enzymes for nanocatalytic therapy. Bi@PVP@AuPt nanoparticles can accumulate in tumor sites and degrade endogenous glucose and hydrogen peroxide, to produce cytotoxic reactive oxygen species in tumor cells, while the loose structure of the wonton-like shape allows for better contact between the substrate and the nanoparticles. At the same time, the Bi@PVP@AuPt nanoparticles can be stimulated by near-infrared laser, leading to the hyperthermia-inducing apoptosis of tumor. Moreover, Bi@PVP@AuPt nanoparticles also showed favorable imaging effects of X-ray computed tomography, photoacoustic, and infrared thermal imaging, which can also assist clinical diagnosis and precise treatment.