Central role of arachidonate 5-lipoxygenase in the regulation of cell growth and apoptosis in human prostate cancer cells

Dietary fat and the risk of prostate cancer: Prostate cancer has emerged as the most frequently diagnosed malignancy among men in the United States, taking thousands of lives every year (1). It is a multistep disease. In the United States, while there are more than 15 million men with localized prostate cancer, only 40–50,000 men will develop malignancy and die in a given year. Thus the development of the metastatic phenotype is an important rate limiting step in the natural history of prostate cancer. Through the incidence of the latent form of the diseases the same worldwide, there is significant geographic variation in the diagnosis of clinically evidence prostate cancer and mortality (2–4) suggesting involvement of environmental factors in this process. Moreover, people who migrate from low-incidence countries to high-incidence countries show increased risk of invasive prostate cancer (5–8) indicating a positive role for lifestyle factors, such as diet and nutrition.