Modulation of the stimulus effects of morphine by d-amphetamine.
1998
Abstract The stimulus effects of morphine and d -amphetamine coadministration were studied in rats. Place conditioning, drug discrimination, and taste conditioning were employed to assess the rewarding, discriminative, and aversive stimulus properties of both drugs. d -Amphetamine increased the rewarding and morphine-like discriminative stimulus effects of 1.25 mg/kg morphine. d -Amphetamine did not, however, change the aversive effects of 1.25 mg/kg morphine, or any effect of higher (5–20 mg/kg) morphine doses. Because the rewarding/discriminative properties and the aversive properties of a drug are considered the main attributes that regulate (facilitate and weaken, respectively) drug-seeking behavior, the present data are in keeping with clinical reports indicating that amphetamines are sometimes used by opiate abusers in an attempt to increase the effect obtained from poor-quality heroin.
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