The Plasma Homocysteine/Creatinine Ratio Can Be Used to Study the Implication of (C677T) MTHFR Genetic Variants in Homocysteine Homeostasis

As discussed in a recent review (1), it is accepted that the determinants of total plasma homocysteine are numerous. The usual factors involved are age, sex, nutritional status, renal function, and genetic status. In this study, we sought to discriminate the influence of the C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene on plasma total homocysteine. We studied a healthy French population (n = 78) with serum folate (9.4 ± 3.2 μg/L, mean ± SD) and plasma creatinine (79.7 ± 12.8 μmol/L) values within the references intervals and of known age, sex, and MTHFR genetic status (41 women, ages 38.2 ± 9.9 years, TT …