Plasma concentration of fibrinopeptide A (FPA), Bβ 15-42 and bradykinin in glomerulonephritis and the nephrotic syndrome

Plasma fibrinopeptide A (FPA), Bβ 15-42 and bradykinin (BK) concentrations were determined in 46 patients with glomerulonephritis and the nephrotic syndrome by radioimmunoassay. An increase in plasma FPA, Bβ 15-42 and BK was noted in patients. Intravascular coagulation with subsequent fibrinolysis and activation of kinin system may occur in patients. A positive correlation was found between Bβ 15-42 and BUN or serum creatinine concentration, suggesting that plasma Bβ 15-42 is influenced not only by plasmin action, but also by renal dysfunction.