32 EVALUATION OF TOLOZOLINE TEST IN THE TREATMENT OF PERSISTENT PULMONARY HYPERTENSION OF THE NEWBORN |[lpar]|PPHN|[rpar]| BY DOPPLER ECHOCARDIOGRAPHY

To reverse pulmonary hypertension and to improve hypoxemia in PPHN, tolazoline (TZ) was tested to assess its ability to decrease pulmonary resistances. We aim to study the response to TZ vasodilation by Doppler echocardiography. We sequentially studied profiles of blood velocities in the left pulmonary artery. Through the second intercostal space, the zero angle incidence beam with the LPA allows reproducibility of repeated measurements. The ductal flow was recorded arid gradient calculated. After baseline, TZ bolus infusion was started at 1 mg/kg for 15 min, then increased by steps of 1 mg/kg if no response. Measurements were done every 5 min during the test.