Genetic variation at the apoB 3'hypervariable region in a Serbian population.

Abstract We investigated common length polymorphism caused by a variable number of tandem repeats in the hypervariable region located at the 3' end of the human apolipoprotein B gene in 696 Serbian (Belgrade area) unrelated individuals of both genders. After using the polymerase chain reaction to amplify this polymorphic region, 17 different alleles, containing 22-54 repeats, were distinguished. The bimodal distribution and the heterozygosity index (average 0.71) obtained in both genders are similar to those reported for other Caucasian populations. However, the HVE34 allele was found to be the commonest in both female and male samples. There was also a lower frequency of the HVE > 36 alleles than in other Caucasian populations studied.