Comments on Rupture of Adsorbed Vesicles

We treat rupture of adsorbed vesicles by using elements of the fracture theory. This approach allows us to estimate the rupture rate constant and, in analogy with the conventional purely thermodynamical analysis, to introduce the critical value of the lipid−substrate interaction and the critical vesicle size for vesicle rupture. In our treatment, these values are however related to the kinetics and accordingly they are dependent (logarithmically) on the time scale of the experiment.