Gastric neuroendocrine tumor with Helicobacter pylori-associated chronic gastritis.

Abstract Introduction Development of gastric neuroendocrine neoplasms in subjects infected withHelicobacter pylori is rare and it occurs through pathogenetic mechanisms related to gastrin. Presentation of case We report a case of gastric neuroendocrine tumor in a patient infected with Helicobacter pylori and normal gastrin levels. He was treated by endoscopic mucosal dissection after eradication of Helicobacter pylori infection. Histologically the tumor was consistent with a grade 2 well differentiated neuroendocrine tumor. It was characterization by the presence of lymphoid aggregates around and inside the neoplasia. Discussion Helicobacter pylori-associated chronic gastritis can rarely cause the development of gastric neuroendocrine tumors through mechanisms unrelated to gastrin. Conclusion The one related to a chronic Helicobacter pylori infection may be considered a distinct type of gastric neuroendocrine tumor.