PRE-binding protein of Plasmodium falciparum is a potential candidate for vaccine design and development: An in silico evaluation of the hypothesis

Abstract Immunity to Plasmodium falciparum is contributed by many known and unknown factors. Lack of effective vaccine and rise in drug-resistant Plasmodium parasites leads to the major challenge in controlling the parasite. Determination of surface or secreted proteins which are essential for the survival of the pathogen is a very important step in finding potential vaccine candidates. Despite the discovery of several vaccine candidates against Plasmodium over the last decades, an effective vaccine is not available. The present study hypothesized that the PRE-binding protein (PREBP) could be a potential vaccine candidate against malaria pathogenesis. PREBP is highly conserved among the class Aconoidasida and exhibit high antigenicity and accessibility as a secretory protein. The present hypothesis was tested by employing in-silico translational genomics wherein the antigenicity, localization and the conservancy were determined.