Dicopper(II) Complexes of p-Cresol-2,6-Bis(dpa) Amide-Tether Ligands: Large Enhancement of Oxidative DNA Cleavage, Cytotoxicity, and Mechanistic Insight by Intracellular Visualization

Dicopper complexes of a new p-cresol-2,6-bis(dpa) amide-tether ligand (HL1), [Cu2(μ-OH2)(μ-1,3-OAc)(L1)](ClO4)2 (1) and [Cu2(μ-1,1-OAc)(μ-1,3-OAc)(L1)]X (X = ClO4 (2a), OAc (2b)) were synthesized a...