Specificity of Design to Achieve Antagonists of LHRH of Increasing Effectiveness in Therapeutic Activity

The pioneering work on TRH [1–4] inspired the staff of the Institute for Biomedical Research of the University of Texas at Austin to isolate concentrates of LHRH from tissue and conduct chemical and enzymic inactivation experiments toward determining certain amino acids in LHRH. These studies [5] resulted in the crucial conclusion that LHRH is a decapeptide rather than a nonapeptide [6]. These inactivation experiments not only provided accurate structural information, but were the basis for the synthesis of

Keywords:

• LHRH Agonist
• Amino acid
• Luteinizing hormone
• Pharmacology
• Chemistry

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