Эпигенетическое репрограммирование ДНК в гаметах и доимплантационных эмбрионах человека

In this review, we present recent data on the epigenetic reprogramming in human gametogenesis and preimplantation embryogenesis. We summarize current knowledge on the dynamic changes of DNA methylation - the key mechanism of genome epigenetic regulation - in gametes and preimplantation embryos. We also discuss the differences in dynamics and mechanisms of imprinted and non-imprinted regions reprogramming in male and female germ cells.