Rhodium(I)-Catalyzed Arylation of β-Chloro Ketones and Related Derivatives through Domino Dehydrochlorination/ Conjugate Addition

Highly efficient arylations of b-chloro ke- tones and their ester and amide derivatives were achieved by means of domino dehydrochlorination/ Rh(I)-catalyzed conjugate addition. In situ generat- ed vinyl ketones and their analogues were identified as the reaction intermediates. The present synthetic protocol provides a concise route to (chiral) b-aryl ketones, esters, and amides.