Pre- and/or Postsurgical Administration of Estradiol Benzoate Increases Skin Flap Viability in Female Rats

Background It has been shown that estrogens have a protective effect with regard to tissue ischemia. Therefore, in this macroscopic and histological investigation, the effect of estradiol benzoate on skin flap viability was studied in sham-operated and ovariectomized Sprague-Dawley rats.