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Pharmacology of Calcium Channel

2020 
Calcium channel plays a very crucial role in the regulation of various vital functions of the body. The effects and modes of action of various drugs on calcium channels have been outlined with every detail. The pharmacology of various subunits and subtypes of this channel has been discussed in view of drug development in the near future. The role of Cav1 channel in health problems such as Parkinson’s disease, cardiovascular diseases, subtypes of Cav2 channels in terms of G-protein inhibition and synaptic vesicle release, Cav3 channels for peptide toxins, and α2δ ligands in amino acid transportation and synaptic transmission has been highlighted in the literature. Diseases like obesity, epilepsy, and anxiety can be treated easily by targeting the T-type calcium channel which is one of the best potential therapeutic targets for the aforesaid diseases. In epilepsy and neuropathic pain, α2δ subunit is the most prominent area of therapeutic target by the gabapentinoid drugs. Thus, scientific research on calcium channel pharmacology may become revolutionary in the management of various chronic diseases. In this chapter, all possible attention has been given to describe the super selectivity of different subtypes of calcium channels by focusing on isoforms of channels and biophysical properties in various target tissues.
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