Antigen-binding molecule containing modified antibody variable region

The inventors have succeeded in creating an antigen-binding molecule containing an antibody variable region, the molecule having binding activity to a molecule expressed on the surface of T cells and to a molecule expressed on the surface of another immune cell, but not binding simultaneously to both. The present invention enables the creation of an antigen-binding molecule that can prevent side effects that can occur when T cells and other immune cells crosslink, and provides an antigen-binding molecule that is suitable as a drug.