Effects of norethisterone on pressor response to angiotensin II in men

Objective: We examined the effects of norethisterone and/or mestranol on the pressor response to angiotensin II in 20 healthy men. Methods: Four study protocols were used: I) mestranol 0.08 mg/day for 6 days followed by mestranol plus norethisterone 20 mg/day for 6 days, II) mestranol 0.16 mg/day for 6 days followed by norethisterone alone 10 mg/day for 6 days, III) mestranol 0.24 mg/day followed by norethisterone 20 mg/day for 6 days, and IV) norethisterone 20 mg/day for 6 days