A simple and one-pot synthesis of 2,3,4,5-tetrasubstituted 4,5-dihydro-3H-1,4-benzodiazepines
2013
Abstract 2,3,4,5-Tetrasubstituted 4,5-dihydro-3 H -1,4-benzodiazepines were synthesized in one-pot by a new sequential Ugi 4CC/Staudinger/aza-Wittig reaction, starting from easily accessible o -azidobenzaldehyde, α-amino ketone hydrochloride, isocyanide and carboxylic acid.
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