Relationship between ganglion cell-inner plexiform layer and optic disc/retinal nerve fibre layer parameters in non-glaucomatous eyes

Aims To determine the relationship between macular ganglion cell–inner plexiform layer (GC-IPL) thickness and optic disc/retinal nerve fibre layer (RNFL) parameters in non-glaucomatous eyes measured by spectral-domain optical coherence tomography (SD-OCT). Methods 491 non-glaucomatous Chinese aged 40–80 years were recruited from a population-based study and underwent standardised ophthalmic examination. SD-OCT was used to measure GC-IPL thickness, optic disc parameters and RNFL thickness. Univariate and multiple linear regression analyses were performed to assess the association between GC-IPL and optic disc/RNFL parameters. Results In univariate analyses, all RNFL parameters and rim area were significantly correlated with all macular GC-IPL parameters (p Conclusions Our study demonstrated only fair correlations between macular GC-IPL and optic disc/RNFL parameters measured by SD-OCT. This information is important for further evaluation of macular GC-IPL thickness as an additional marker in detecting glaucomatous damage and progression.