Clinicopathological Study of Minimal Deviation Adenocarcinoma of the Cervix

Objective:This study was to evaluate the clinicopathological features and diagnosis of minimal deviation adenocarcinoma(MDA).Methods:The medical records and clinicopathological results of 16 patients with MDA were retrospectively reviewed.Results:The most common compliant was a large amount of watery vaginal discharge,Histologically,tumor cells were well differentiated.Glands deeply invaded into cervical stroma,and commonly with vascular space invasion and specific periglandular stromal reaction.Conclusions:Cervical pap smear is necessary for early diagnosis when there is symptom,deep cervical biopsy should be done,even conization to get proper diagnosis.Diagnosis of MDA mainly depends on the clinical symptoms and pathological features which include deep gland invasion,vascular space invasion and specific pariglandular stromal reaction.Radical surgery and adjuvent chemoradiation might be the proper choice.