Studies of the effect of Prostaglandin E1 on lipid metabolism

Prostaglandins are a type of hormone which are synthesized in the organism from highly unsaturated fatty acids through three or more double agglutinations. It was shown recently that these substances inhibit the activation of the triglyceride lipase sensitive to hormones in the fatty tissues. The authors demonstrated through experiments done on animals that prostaglandin E1 not only slows down the hightened lipolysis in the fatty tissues during the state of hunger or in the case of diabetis mellitus but also influences the heparin-induced activation of the lipoproteine lipase. The blood-chemical reactions after intra-aortic application of PGE1 are characterized by a decrease in unsaturated fatty acids saturated fatty acids acetone substances and free glycerines in the blood as well as by an increase in blood sugars. These results lead the authors to suppose that prostaglandin E1 restricts the lipolyse and the fat transformation on one hand and reinforces the metabolism of glucose on the other hand.