Rosehip (Rosa canina) Extracts Prevent Cell Proliferation and Migration in Triple Negative Breast Cancer Cells

Triple Negative Breast Cancer (TNBC) is an aggressive form of breast cancer, characterized by its lack of the human epidermal growth factor receptor-2, the estrogen receptor, and the progesterone receptor. Akt and MAPK have been shown to promote cell proliferation in TNBC. Currently, the existing targeted therapy is of minimal benefit in TNBCs. Natural products have received growing interest as an alternative medicine with potential anti-oncogenic properties. Rosehip extracts have been used as dietary supplements to relieve symptoms associated with gastrointestinal disorders and arthritis, and in our laboratory it has been shown to prevent cell proliferation in glioblastomas. This study investigated the efficacy of rosehip extracts in preventing proliferation and migration of a TNBC cell line (HCC1806). HCC1806 cells treated with rosehip extracts (1mg/mL -25ng/mL) demonstrated a significant decrease in cell proliferation and migration. Additionally, pretreatment of this cell line with rosehip extracts dec...