Clinical course of seizures in patients with cerebral venous thrombosis (P5.3-016)

Objective: We aimed to evaluate the clinical course and investigate association of seizures with clinical, EEG and neuroradiological findings in CVT. Background: Seizures are among the main presenting symptoms of cerebral venous thrombosis (CVT) but predictive factors for seizures are not clear yet. Design/Methods: We included consecutive patients, diagnosed with CVT who had a follow- up of at least one year. The clinical characteristics, neuroimaging and EEG data, recurrence of seizures and response to antiepileptic drugs (AEDs) were investigated. Results: Of 23 patients (mean age:34.1±3.8, follow-up duration:3.8±2.7 years, 13 females), 9 (8 females; p:0.03) presented with seizure at the time of diagnosis of CVT. The seizures recurred in 4 patients and only 2 of them (22%) had seizures resistant to AEDs beyond the 1st month of CVT onset. The recurrence of seizures was not related to the type of seizure or the presence of status epilepticus. Most of the patients with seizures had a single sinus involvement, with a variable distribution. Venous infarcts and/or hemorrhagic transformation were more frequent in the patients with seizures (77% and 44% respectively) than those without seizures (42% and28% respectively). Seizures occurred mostly in the postpartum period (66%) or in those patients with thrombophilia (66%). Conclusions: Seizures are seen in 39.1% of the patients in the acute phase of CVT, with a significant female dominance. A minority (8.7%) may experience recurrent and AED-resistant seizures, which do not have a specific association with clinical, EEG and neuroradiological findings. Disclosure: Dr. Uygun has nothing to disclose. Dr. Ekizoglu has nothing to disclose. Dr. Barlas-Yesilot has nothing to disclose. Dr. Baykan has nothing to disclose.