Multi-step Parallel Synthesis Enabled Optimization of Benzofuran Derivatives as Pan-genotypic Non-nucleoside Inhibitors of HCV Targeting the Palm II Binding Site of NS5B

Abstract In a lead optimization effort towards NS5B NNI inhibitors, two multi-step parallel libraries were designed and successfully synthesized. Through this effort we discovered compound 9B, which achieved rigorous and delicate balance of inhibition across the common genotypes and mutants with