Effect of Ammonia Plasma Treatment on the Biological Performance of Plasma Polymerized Hexamethyldisiloxane

Plasma polymerized hexamethyldisiloxane (PPHMDS) is a polymer frequently considered for biomedical application due to its easy fabrication, low cost and biocompatibility. However, a drawback of using PPHMDS in osteosubstitutive engineering is its high hydrophobicity, causing extremely low cellular interaction. Surface wettability can be altered in many ways such as plasma treatment, surface coating, introduction of hydrophilic or hydrophobic groups by self‐assembled monolayers, etc. Among all these methods plasma treatment is one of most effective and economical ways to modify surface wettability of a material. Here, we investigated three different PPHMDS layers prepared by plasma polymerization (PP) of HMDS on cover glass (CG) under two different technological regimes. In order to improve cellular interactions, PPHMDS films obtained by the second operating mode were further hydrophylized in NH3 plasma. Cell‐biomaterial interactions were characterized by human osteoblast‐like MG63 cell model, where overal...