2,4-substituted benzene-1,5-diamine derivatives and their use as well as pharmaceutical compositions and pharmaceutical compositions prepared therefrom

The present invention provides a class of 2,4-substituted-1,5-phenylene diamine derivative and pharmaceutically acceptable salt, stereoisomer, solvate inhibited the EGFR tyrosine kinase or before medicine. Wherein the definition of each group in the description detailed. Further, the present invention also discloses a pharmaceutical composition comprising the compound, pharmaceutical compositions and uses thereof.