Генетический риск развития гиперпластического процесса в эндометрии и в молочных железах, ассоциированный полиморфизмом генов-кандидатов

The purpose of research to improve timely diagnosis of diseases of the endometrium and hyperplastic mammary glands on the basis of molecular genetic testing for carriers of candidate genes. All patients were divided into four groups according to the identified endometrial hyperplasia and mammary glands. Group I included 41 patients with hyperplastic process, localized only in the mammary glands and without GGE (23,3 %); II group 37 patients with GGE and unaltered breasts (25,5 %); III group 52 women with sochetannym hyperplastic process and in the mammary glands and the endometrium (35,9 %); IV group (control) 15 women (10,3 %) having no hyperplastic diseases of the reproductive system. Comprehensive survey of women with endometrial hyperplastic processes and mammary glands, which includes, along with an analysis of clinical and anamnestic data, the study of genetic predisposition to these multifactorial diseases and tissue receptivity to steroid hormones, demonstrates the possibility of early diagnosis and prediction of the behavior of their clinical course, which is extremely important for the development of adequate therapeutic measures.