109 LONG TERM EFFICACY AND SURVIVAL IN PATIENTS TREATED WITH THE GUT-SELECTIVE ANTIBIOTIC RIFAXIMIN (550 MG BID) FOR THE MAINTENANCE OF REMISSION FROM OVERT HEPATIC ENCEPHALOPATHY

(F0-F1 12.0 kPa). Genotypes were determined using Taqman assays. Results: Most patients suffered from chronic viral hepatitis C (58.9%), followed by alcoholic (10.6%) and autoimmune (AIH, PBC, PSC) liver diseases (8.1%). Mean 25(OH)-vitamin D3 levels were 28.4±15.8 ng/ml. Patients with advanced fibrosis (>12.0 kPa) had significantly lower 25(OH)-vitamin D3 levels as compared to patients with 7.0 kPa), the rare allele was significantly associated with increased liver stiffness (TT & TG vs GG: 5.1±1.0 kPa vs. 5.4±1.0 kPa; p < 0.05). Conclusion: A common SNP close the DHCR7 gene is associated with 25(OH)-vitamin D3 serum concentrations in patients with chronic liver disease. Interestingly, the association of this SNP with liver fibrosis was restricted to patients with no or mild fibrosis, suggesting that the modifier effect of vitamin D might only be discernible during fibrosis initiation and early fibrosis stages.