Comparison of the Therapeutic Effects of Oral or Intravenous VP-16 plus CTX ADM and PDN Regimen for Non-Hodgkin's Lymphoma

Objective To evaluate the clinic results of oral or intravenous VP-16 plus cyclo-phosphamide (CTX),Adriamycin(ADM),and prednisone (PDN) regimen for non-Hodgkin's lymphoma (NHL). Methods 47 cases of cytological and pathological confirmed advanced NHL were treated with CHEP regimen,the patients were randomly divided into two groups. 23 Cases with non-Hodgkin's lymphoma were in oral group,while 24 cases were in iv drip group.All patients received no previous treatment.Treatment was repeated every 3～4 weeks for the two groups.Results The complete response rate of the two groups were 39.1% (9/23) and 41.7% (10/24).The overall response rates of the two groups were 73.9%(17/23) and 79.2%(19/24).The were no statistically significant difference between the two groups ( P 0 05).The major toxic effects were gastrointestinal reaction,alopecia and similar myelosuppession.Conclusions The combined chemotherapy Oral or intravenous VP-16 plus cyclophosphamide(CTX),Adriamycin (ADM),and prednison (PDN) regimen is worthy of use in the treatment of non-Hodgkin's lymphoma.