A PROCESS FOR THE PREPARATION OF OPTICALLY PURE D(+) BROMPHENIRAMINE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS

A new synthesis for the preparation of optically pure D(+)-3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine (Brompheniramine) and its pharmaceutically acceptable salts by efficient and cost-effective process for obtaining highly optically pure Dexbrompheniramine in high yield by the resolution of a racemic mixture of 3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine (brompheniramine base) with a (+)4-nitro tartranilic acid(PNTA) as a resolving agent in the presence of a alcoholic solvent system with the simultaneous recovery of the (+)4-nitro tartranilic acid(PNTA) as well as recovery of undesired (Levo)-isomer of brompheniramine and traces (Dextro)-isomer and racemization thereof to racemic mixture of brompheniramine for use in the process of the invention so as to minimize wastage of the reactants.