Associations ofresting heart ratewith concentrations oflipoprotein subfractions in sedentary men

Inmajor prospective studies ithasbeenreported that highheart rateatrestpredicts the development ofcoronaryheart disease (CHD)or cardiovascular disease (CVD)inmen, butthe mechanisms producing these relationships areunknown. Since lipoprotein levels contribute strongly to therisk ofCHDandCVD,we examined therelationship ofresting heart ratetoplasma concentrations ofhigh-density (HDL), low-density (LDL), andverylow-density (VLDL)lipoproteins, apolipoprotein (apo) A-IandA-IL, andserumconcentrations oflipoprotein subfractions in81men todetermine if atherogenic lipoproteins could potentially induce thereported association ofheart ratewithdevelop- mentofCHDorCVD.Thesignificant (p .05) Spearman's correlations forresting heart rate vsHDL2 mass(rs = - .24), HDL3mass(r, = - .40), HDL cholesterol (rs = - .36), apoA-I(rs = - .29), triglycerides (r, = .31), VLDLcholesterol (r, = .24), VLDLmass(rs = .27), andLDLmassofSO 0-7subfraction (rs = .30) lendsupport toourhypothesis oflipoprotein-indu