Pustulosis exantemática generalizada aguda secundaria a hidroxicloroquina

Acute generalized exanthematous pustulosis (AGEP) is a rare skin eruption most commonly caused by medications. It is characterized by an acute eruption of sterile pustules and it is accompanied by an episode of fever, which regresses a few days after discontinuation of the drug that caused the condition. We report a case 23 year-old woman without history of psoriasis, that consults for fever and an acute generalized pustular eruption after amoxicillin, with clavulanic acid administration in a mononucleosis infection context, which resolved spontaneously. The microbiologic culture was negative for pathogenic germens. La pustulosis exantematica aguda generalizada (PEAG) es una rara afeccion de hipersensibilidad, inducida principalmente por drogas y se manifiesta por una erupcion aguda de pustulas esteriles, acompanada de fiebre, que regresa en pocos dias luego de discontinuar el farmaco causante. Se comunica el caso de una paciente de 23 anos de edad, sin antecedentes de psoriasis que consulta por fiebre y una erupcion pustulosa generalizada, asociada a la ingesta previa de amoxicilina y acido clavulanico en el contexto de una mononucleosis infecciosa, con resolucion espontanea del cuadro. El cultivo microbiologico no objetivo germenes patogenos.