The Study of Gubentongluochongji on Experimental IgA Nephropathy

Objective:To study the mechanism of Chinese herbal compoud Gubentongluochongji(GBTLCJ)on experimental IgA Nephropathy(IgAN). Methods: Forty BALB/C male mices were randomized into four groups: normal control group, IgAN control group,GBTLCJ treated group and persantin control group. We observed its effect of treatment on mice with IgAN was induced by oral 0.1% BSA and intravenous SEB. Results: Animal experimental study indicated:GBTLCJ not only decreased proteinuria.but al so had aignificaut effects in ameliorating renal lesion and regulating the metabolism of SOD, GSH- PX and MDA.Conclusion:GBTLCJ is an effective Chinese herbal compoud on IgAN.The mechanism may include increasing SOD and GSH- PX,resisting lipid peroxidation in renal tissue and ameliorating renal lesion.