COMMD3:BMI1 fusion and COMMD3 protein regulate C-MYC transcription: Novel therapeutic target for metastatic prostate cancer

Gene rearrangement is reported to be associated to the aggressive phenotype and poor prognosis in prostate cancer (CaP). We identified a gene-fusion between a transcription repressor (BMI1) and transcriptional factor (COMMD3) in human CaP. We show that COMMD3:BMI1 fusion expression is significantly increased in CaP disease in an order: normal tissue