Effect of registration mode on neuronavigation precision: an exploration of the role of random error.

The aim of this paper is to analyze the variations in registration accuracy for computer-assisted surgical navigation using three different modes of registration, in order to explore the behavior of random error, and to highlight the precision of neuronavigation as a concept distinct from accuracy.The operational accuracy of three different registration modes (bone fiducials, scalp adhesive fiducials and an auto-registration mask) was evaluated in a total of 20 fresh cadaveric heads. The precision of the neuronavigation system was then assessed by evaluating the variation in the accuracy measurements associated with each registration mode. The coefficient of variation was employed to quantify the degree of variation in the attained accuracy using the following formula: Coefficient of variation = standard deviation/mean * 100.For external targets, the precision of the neuronavigation system was greatest with mask registration (43.75 and 51.41 for anterior and posterior external targets, respectively) and l...