The Attentive Focus on T Cell‐Mediated Autoimmune Pathogenesis of Psoriasis, Lichen planus, and Vitiligo
2020
T cell-mediated autoimmune skin diseases develop as a result of the aberrant immune response to the skin cells with T cells playing a central role. These chronic inflammatory skin diseases encompass various types including psoriasis, lichen planus, and vitiligo. These diseases show similarities in their immune-pathophysiology. In the last decade, immunomodulating agents have been very successful in the management of these diseases thanks to a better understanding of the pathophysiology. In this review, we will discuss the immunopathogenic mechanisms and highlight the role of T lymphocytes in psoriasis, lichen planus, and vitiligo. This study could provide new insights into a better understanding of targeted therapeutic pathways and biological therapies.
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