CRP and gender differences in patients with acute myocardial infarction

Objective. Inflammation appears to be pivotal in all phases of atherosclerosis from the endothelial dysfunction to acute coronary syndromes. An important marker of inflammation is C-reactive protein (CRP). The sex hormones estrogen and testosterone have been shown to modify the inflammatory response by influencing cytokine expression in human macrophage cells. Method. Our retrospective study included 147 patients (73 patients with STEMI, 44 with NSTEMI) and 30 controls. Information about demographic characteristics, CRP values (at admission) we collected using clinical files. All results were carrying out using Student T test and binary logistic regression. P values =<0.05 were considered statistically significant. Results. CRP difference in 117 patients with acute myocardial infarction (73 patients with STEMI and 44 patients with NSTEMI) and 30 healthy individuals (controls) is statistically significant (p=0.001). CRP difference between male and female is statistically significant in patient with STEMI (25,14 ± 29,23 versus 13,16 ± 17,05, p =0,038), but not in NSTEMI patients. Observing CRP, gender and age in binary logistic regression, only CRP increases risk for acute myocardial infarction, OR=1,952. Conclusion. CRP value is higher in patients with acute myocardial infarction and shows gender difference, higher values are in women with STEMI.