Association of rs9939609 FtO gene polymorphism with metabolic syndrome and its components in russian population

Abstract Objective. To study the association of genetic determinant (A-risk allele of rs9939609 SNP of FTO gene) with prevalence of metabolic syndrome (MS) and its components in residents of different Russian cities. De- sign and methods. We examined 425 patients with MS or its components from different cities of Russia (St Petersburg, Kursk, Kaliningrad), stratified by sex and age [175 male (41,2%) and 250 female (58,8 %), mean age — 47,2 ± 0,6 years]. All subjects were interviewed with special questionnaire. Physical examination included anthropometry (waist and hip circumferences, weight, height), blood pressure and heart rate registration. MS was defined according to NCEP-ATPIII as well as IDF (2005) and JIS (2009) criteria. Fasting plasma lipids and glucose were performed in all patients by Hitachi-902 equipment (Roche reagents). Genomic deoxyribonucleic acid (DNA) was purified from peripheral blood lymphocytes and genotyping was performed using real time polymerase chain reaction method by allele-specific probes (Applied Biosystems). Results. Among males with AA genotype waist and hip circumferences and weight were higher, compared to subjects with TA and TT geno-types (p = 0,0002, p = 0,001 and p = 0,01, respectively). There was a tendency to the increase of body mass index (BMI) in the group with AA genotype compared to subjects with TA and TT genotypes (29,7 ± 0,7; 27,6 ± 0,4 and 27,9 ± 0,3 kg/m², respectively, р = 0,1). In our study AA genotype was associated with higher glucose level compared to TA and TT genotypes (5,6 ± 0,2; 5,0 ± 0,1 and 5,1 ± 0,1 mmol/l, respectively, p = 0,04). There was a tendency to the increase of the proportion of hypertensives among patients with AA genotype compared to TA and TT genotypes (70,5; 65,2 and 57 %, respectively, p = 0,18). Conclusion. In Russian population FTO gene polymorphism rs9969309 is associated not only with abdominal obesity, but also with other components of MS, including hyperglycemia and hypertension.Key words: metabolic syndrome, abdominal obesity, hypertension, dyslipidemia, hyperglycemia, rs9939609 FTO gene polymorphism. Статья поступила в редакцию: 19.09.13. и принята к печати: 01.10.13.избыточная масса тела [4, 5]. Широкое распро-странение ожирения характерно и для российской популяции. Так, по данным эпидемиологического исследования среди населения ряда российских городов зарегистрирована высокая встречаемость абдоминального ожирения (АО), в особенности среди женщин [6]. АО как независимый фактор риска развития сердечно-сосудистой патологии и как один из главных компонентов метаболиче-ского синдрома (МС) давно привлекает внимание врачей-исследователей с целью изучения меха-низмов его возникновения, анализа взаимосвязи с различными факторами, в частности, с наслед-ственными факторами. Известно, что АО может привести к развитию инсулинорезистентности,