Which PrP haplotypes in a French sheep population are the most susceptible to atypical scrapie

Carole Moreno,Katayoun Moazami-Goudarzi,Pascal Laurent,G. Cazeau,Olivier Andréoletti,S. Chadi,J. M. Elsen,D. Calavas

Which PrP haplotypes in a French sheep population are the most susceptible to atypical scrapie

2007

Carole Moreno
Katayoun Moazami-Goudarzi
Pascal Laurent
G. Cazeau
Olivier Andréoletti
S. Chadi
J. M. Elsen
D. Calavas

A French sheep case control study has been organised to estimate the effects of the PrP haplotypes on resistance to atypical scrapie. The ALHQ and AFRQ haplotypes are significantly more susceptible than the others.

Keywords:

Virology
Scrapie
Biology
Haplotype
Degenerative disease
Case-control study
Immunology
Spongiform encephalopathy
Population
classical scrapie
prion protein
prnp gene
on resistance

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