Acute Dyspnea After Platelet Transfusion

Transfusion-associated lung injury (TRALI) is defined as the onset of acute, non-cardiogenic pulmonary edema within 6 h of transfusion and the absence of pre-existing acute lung injury Diagnostic findings are hypoxia (O2 saturation < 90% in room air), a PaO2/FiO2 ratio < 300 mmHg and new bilateral pulmonary infiltrates. With O2 supplementation, up to 72% of cases of TRALI resolve within 48–96 h High dose steroids have no benefit in TRALI