Association of genetic variants of the histamine H1 and muscarinic M3 receptors with BMI and HbA1c values in patients on antipsychotic medication

Jelle Vehof,Arne J. Risselada,Asmar F. Y. Al Hadithy,H. Burger,Harold Snieder,Bob Wilffert,Johan Arends,Lex Wunderink,H. Knegtering,Durk Wiersma,Dan Cohen,Hans Mulder,Richard Bruggeman

Association of genetic variants of the histamine H1 and muscarinic M3 receptors with BMI and HbA1c values in patients on antipsychotic medication

2011

Jelle Vehof
Arne J. Risselada
Asmar F. Y. Al Hadithy
H. Burger
Harold Snieder
Bob Wilffert
Johan Arends
Lex Wunderink
H. Knegtering
Durk Wiersma
Dan Cohen
Hans Mulder
Richard Bruggeman

Rationale Antipsychotic affinity for the histamine H1 receptor and the muscarinic M3 receptor have been associated with the side effects weight gain, and development of diabetes, respectively.

Keywords:

Antipsychotic
Internal medicine
Histamine
Muscarinic acetylcholine receptor M3
Histamine H1 receptor
Muscarinic acetylcholine receptor
Endocrinology
5-HT2C receptor
Metabolic syndrome
Medicine
Muscarine
Pharmacology
glucose homeostasis

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