Abstract 14888: Association of Interatrial Conduction and Diffuse Left Ventricular Myocardial Fibrosis Defined by Cardiac Magnetic Resonance: the PRIMERI Study

Background: Abnormal P-terminal force in V1 (PTFV1) is associated with an increased risk of heart failure, stroke, atrial fibrillation (AF) and death. Our goal was to explore the associations of left ventricular (LV) diffuse myocardial fibrosis with electrocardiographic (ECG) measures of left atrial (LA) electrical activity. Methods: 101 patients (mean age 60.13, 64.36% men, 67.33% Caucasian) with structural heart disease (wide spatial QRS-T angle ≥105° ± Selvester QRS score ≥5 on ECG) but LV ejection fraction >35% underwent clinical evaluation, cardiac magnetic resonance (CMR), and resting ECG. LA function indices (LA volume index) were obtained by multimodality tissue tracking with CMR using 2 and 4 chamber long-axis images. T1 mapping and late gadolinium enhancement (LGE) methods were used to assess diffuse LV myocardial fibrosis and the presence of scar. Amplitude, duration of P-prime in V1 (PPV1), averaged P-duration, PR interval and P-axis were automatically measured using 12SL TM algorithm. PTFV1 w...