Meta-analysis of effectiveness of omeprazole and other drugs in treatment of active peptic ulcer and bleeding

AIM: To explore the difference of efficacy between omeprazole and other drugs in treatment of active peptic ulcer and bleeding. METHODS: The efficacy of omeprazole or other drugs in treatment of active peptic ulcer and bleeding was analyzed by Meta-analysis in homogeneity test and combined test in 9 studies. RESULTS: Homogeneity test showed that the cited studies were homogeneous with χ2= 9.84 , P 0.05 ; and in combined test, the combined OR=4.42 and its 95% confidence interval was in 2.83 - 6.68 (χ2= 44.4 , P 0.01 ). CONCLUSION: Omeprazole is a very effective and well-tolerated proton pump inhibitor and it is worthy of being recommended for administration in patients with active peptic ulcer and bleeding.